Research Paper Volume 11, Issue 3 pp 908—920

Genetical modification on adipose-derived stem cells facilitates facial nerve regeneration

Figure 4. Transplantation of either ASCs-miR-449 or ASCs-shPLOD1 exerts better functional facial nerve regeneration than ASCs in rats. Transplantation of either ASCs-shPLOD1 or ASCs-miR-449 or ASCs-control to repair a 6mm-gap in rat facial nerve was compared. The rats were kept for 8 weeks after surgery. (A) The measurement of vibrissae movement grade in 8 weeks after surgery. (B-D) CAMPs analysis at 8 weeks, showing amplitude (B), duration (C) and latency (D) values. (E-F) The number of the myelinated fibers, shown by representative images (E), and by quantification (F). *p<0.05. NS: non-significant. N=10. Scale bars are 50µm.