Research Paper Volume 11, Issue 3 pp 1030—1044

Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice


Figure 2. Resveratrol improved renewal capacity of OSCs in chemotherapy mice. (A) Dual immunostaining for BrdU (red) and DDX4 (green) of OSCs (arrow) were observed near the surface epithelium of mouse ovaries in the (a) Blank, (b) Chemo, (c) 30 Res and (d) 100 Res groups. Scale bar, 200 μm (B) Relative mRNA expression of c-KIT, Oct4, Sox2, Nanog, Gdf9 and Ddx4 in the different groups. *p < 0.05; **p < 0.005; ***p < 0.001.