Research Paper Volume 11, Issue 4 pp 1151—1162

DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways

Figure 1. DRm217 improved and ouabain worsened renal function. Serum BUN content (A) and serum creatinine content (B) were detected. The increased serum BUN and creatinine levels were blunted by DRm217 treatment. In contrast, ouabain treatment elevated these parameters. Means±SEM, n=6-8; ** p<0.01, vs control group; # p<0.05, ## p<0.01, vs NX group.