Research Paper Volume 11, Issue 4 pp 1151—1162

DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways

Figure 2. DRm217 alleviated but ouabain strengthened kidney morphological damage. (A) Represent images of HE staining for renal cortex. Representative photomicrographs of glomerulosclerosis, tubular dilation and degeneration (black arrow), and protein deposition (red arrow) were observed. (B) Represent images of HE staining for renal medulla. Representative photomicrographs of muddy brown casts (black arrow) were observed. (C) Calculated results of glomerulosclerotic index. (D) Calculated results of Tubule interstitial score. n=6-8. Means±SEM; *** p<0.001, vs control group; # p<0.05, ## p<0.01, ###p<0.001, vs NX group. Scale bar, 100 μm.