Research Paper Volume 11, Issue 4 pp 1151—1162

DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways

Figure 8. DRm217 and PP2 attenuated but ouabain strengthened AngII effect on increasing of collagen I, malondialdehyde and IL-1β in HK-2 cell. mRNA level of collagen I (A), contents of malondialdehyde contents (B), and contents of IL-1β (C) in different-treated cells. AngII increased the expression of collagen I, malondialdehyde and IL-1β, whereas, DRm217 and PP2 decreased but ouabian increased the expression of collagen I, malondialdehyde and IL-1β in AngII-treated cells. n=4. Means±SEM; * p<0.05, **p<0.01, vs control group (Con); # p<0.05, ## p<0.01, vs AngII group.