Editorial Volume 11, Issue 4 pp 1075—1076

Figure 1. Dual action of PI3Kγ inhibitors in AIC. PI3Kγ inhibition protects against anthracycline-induced cardiotoxicity by boosting autophagic clearance of damaged mitochondria and preventing a maladaptive metabolic rewiring of cardiomyocytes. Furthermore, PI3Kγ blockade synergizes with the anticancer action of anthracyclines, and delays tumor growth by activating specific subsets of tumor-associated macrophages. Overall, PI3Kγ inhibitors may be the stone to simultaneously kill the two angry birds of cardiotoxicity and cancer.