Research Perspective Volume 11, Issue 3 pp 1065—1068

Hallmarks of the cancer cell of origin: Comparisons with “energetic” cancer stem cells (e-CSCs)

Figure 2. Cancer stem cell of origin. The cancer stem cell of origin would be predicted to have a chimeric- or hybrid-phenotype, retaining elements of i) senescent cells, ii) cancer cells, and iii) stem cells, as we observe in e-CSCs.