Research Paper Volume 11, Issue 4 pp 1204—1225

m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas

Figure 5. Relationship between the risk score, clinicopathological features and RM1/2 subgroups. (A) The heatmap shows the expression levels of the seven m6A RNA methylation regulators in low- and high-risk gliomas. The distribution of clinicopathological features was compared between the low- and high-risk groups. *** P<0.001 (B–H) Distribution of risk scores in the CGGA dataset stratified by WHO grade (B), TCGA subtype (C) age (D), IDH status (E), 1p/19q codel status (F), gender (G) and RM1/2 subgroups (H). **P < 0.01, and ****P < 0.0001. (I-L) ROC curves showed the predictive efficiency of the risk signature, WHO grade, and age on the three-year survival rate (I), RM1/2 subgroups (J), IDH-mutant status (K) and 1p/19q codel status (L). (M-N) Univariate and multivariate Cox regression analyses of the association between clinicopathological factors (including the risk score) and overall survival of patients in the CGGA (M) and TCGA (N) datasets. ns no significance, *** P < 0.001 and **** P < 0.0001.