Figure 1. Circulating cRAGE but not esRAGE decreases with aging in healthy subjects. cRAGE values were derived by subtracting esRAGE values from the total sRAGE. (A) Bars represent serum levels of total sRAGE, cRAGE and esRAGE in three age groups of a healthy population, young (≤45 yrs; n=35-37), middle age (46-64 yrs; n=66-72) and elderly-old (≥65 yrs; n=59-60). Data are in the original units. Values are expressed as median and interquartile range. **P < 0.01; ***P < 0.0001; Kruskal-Wallis with Dunn’s multiple comparison test. (B) Scatter plots showing correlation between age and sRAGE, cRAGE or esRAGE. Variables showed a skew-ness distribution and were log-transformed. r=Pearson’s coefficient. P<0.05 was considered statistically significant; n=159-169.