Research Paper Volume 11, Issue 6 pp 1778—1790

Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota

Figure 2. Differential profiles of the gut microbiota between the non-POCD and POCD groups. (A) Bray–Curtis diversity distance. (B) Shannon index (t = 3.454, P <.01). (C) Simpson index (t = 2.195, P <.05). (D) PLS-DA analysis of gut bacteria data. (E) PCoA analysis of 7 gut bacteria data (PC3 vs. PC2). α-diversity data are shown as mean ± SEM (n = 7). PCoA: principal coordinate analysis; PLS-DA: partial least squares discrimination analysis. *P <.05, **P <.01.