Research Paper Volume 11, Issue 7 pp 1907—1917

Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma

Figure 5. The oncogenic role of circ_0005230 is partly dependent on its regulation on miR-1238 and miR-1299. (A) Transfection with miR-1238 and miR-1299 inhibitor led to decreased expression of miR-1238 and miR-1299 in circ_0005230-downregulated HuCCT1 cells. (B) Transfection with miR-1238 and miR-1299 mimics led to elevated expression of miR-1238 and miR-1299 in circ_0005230-upregulated KMBC cells. (C, D) Inhibition of miR-1238 and/or miR-1299 rescued the proliferation and invasion of circ_0005230-downregulated HuCCT1 cells. (E, F) Ectopic expression of miR-1238 and/or miR-1299 rescued the proliferation and invasion of circ_0005230-upregulated KMBC cells.*p<0.05, **p<0.01.