Figure 3. Effects of WY peptides on memory impairment induced by LPS. Mice intracerebroventricularly injected with 1.0 mg/kg of LPS at day 0 were orally administered 0, 3, or 30 mg/kg WY peptide from day −2 day to day 5. Mice were subject to the Y-maze test on day 3 and to NORT on days 4 and 5. (A, B) Spontaneous alterations and arm entries during 8 min of exploring in Y-maze to evaluate spatial memory. (C) Time spent exploring novel and familiar objects during 5 min of re-exploration as a percentage of the total time spent exploring objects to evaluate episodic memory. (D) Discrimination index [time spent with object A − time spent with object B] / [total time exploring both objects]. Data are the mean ± SEM of 10 mice per group. p-values shown in the graph were calculated by performing Student t-test (LPS [−] vs. [+] at 0 mg/kg WY peptide) and one-way ANOVA followed by Dunnett test. *p < 0.05 and **p < 0.01.