Research Paper Volume 11, Issue 10 pp 2949—2967

Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline

Figure 6. Effects of WY peptide on Aβ deposition and memory function in 5×FAD mice. For 3 months, 2.5-month-old transgenic 5×FAD and wild-type male mice were fed a diet with or without 0.05% w/w WY peptide. (A, B) The levels of TBS-soluble Aβ1-42 in the hippocampus and frontal cortex, respectively. Data represent the means ± SEM of 12 wild-type mice, 11 control transgenic mice, and 12 transgenic mice fed with a diet containing the WY peptide. Data represent the means ± SEM of 7 mice per group. (C) Spontaneous alterations during 8 min of exploring in Y-maze. (D) Discrimination index in NORT by measuring time spent exploring novel and familiar objects during 5 min of re-exploration. p-values shown in the graph were calculated by one-way ANOVA followed by the Tukey–Kramer test. *p < 0.05.