Research Paper Volume 11, Issue 9 pp 2565—2582

Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Figure 2. Effect of simvastatin on cellular CoQ10 levels and cytotoxicity. Viability (A) and CoQ10 content and oxidative status (B) of human dermal fibroblasts with different doses of simvastatin for 72 h. Data (n=9 A; n=4 B) are reported as mean and standard error of % live cells (A) and coenzyme Q10/total protein (μg/mg) (B). Significance difference vs 0 nM + p<0.05, ++ p<0.01, +++ p<0.001, ++++ p<0.0001.