Research Paper Volume 11, Issue 9 pp 2565—2582

Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Figure 4. Simvastatin promotes senescence markers of cellular senescence in human dermal fibroblasts incubated with different doses of simvastatin for 72 h. Beta-galactosidase positive cells (A). p16 mRNA expression (B); western blot analysis of p16 (C, D). Significance difference vs 0 nM + p<0.05, ++ p<0.01, +++ p<0.001, ++++ p<0.0001.