Research Paper Volume 11, Issue 9 pp 2565—2582

Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Figure 5. Effect of simvastatin on mitochondrial toxicity. Permeability transition pore opening (A) and mtDNA copy number (B) in human dermal fibroblasts in presence of different concentrations of simvastatin for 72 h. Data (n=12 A; n=6 B) are reported as box-plot with 50% of the population reported in the box; horizontal lines indicate min, median, and max values. Significance difference vs 0 nM + p<0.05, ++ p<0.01, +++ p<0.001, ++++ p<0.0001.