Figure 7. Effect of simvastatin on mitochondrial respiratory indexes. Respiratory profile of human dermal fibroblasts incubated with different concentrations of simvastatin for 72 h. Non-mitochondrial respiration (A), basal respiration (B), maximal respiration (C), proton leakage (D), ATP production (E), spare respiratory capacity (F). Data (n=48) are reported as box-plot values of oxygen consumption rate. Significance difference vs 0 nM + p<0.05, ++ p<0.01, +++ p<0.001, ++++ p<0.0001.