Research Paper Volume 11, Issue 9 pp 2565—2582

Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Figure 7. Effect of simvastatin on mitochondrial respiratory indexes. Respiratory profile of human dermal fibroblasts incubated with different concentrations of simvastatin for 72 h. Non-mitochondrial respiration (A), basal respiration (B), maximal respiration (C), proton leakage (D), ATP production (E), spare respiratory capacity (F). Data (n=48) are reported as box-plot values of oxygen consumption rate. Significance difference vs 0 nM + p<0.05, ++ p<0.01, +++ p<0.001, ++++ p<0.0001.