Research Paper Volume 11, Issue 9 pp 2628—2652

Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer

class="figure-viewer-img"

Figure 9.

The mechanism graph of the regulatory network of PIEZO2 under different circumstance including normal (A) and cancer (B). In patients with breast cancer, miRNAs (miR-454-3p, miR-196a-5p, miR-301a-3p, miR-130b-3p and miR-421)-mediated downregulation of PIEZO2 can activate hedgehog signaling pathway by suppressing CDON.