Research Paper Volume 11, Issue 9 pp 2628—2652

Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer

Figure 9. The mechanism graph of the regulatory network of PIEZO2 under different circumstance including normal (A) and cancer (B). In patients with breast cancer, miRNAs (miR-454-3p, miR-196a-5p, miR-301a-3p, miR-130b-3p and miR-421)-mediated downregulation of PIEZO2 can activate hedgehog signaling pathway by suppressing CDON.