Research Paper Volume 11, Issue 9 pp 2670—2680

Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein

Figure 1. Overexpression of TAZ in TRAIL-resistant glioma cells. (A) Drug sensitivity of U251, U251/R, U87 and U87/R cells to TRAIL (0~200 ng/mL). (B) IC50 of TRAIL to U251, U251/R, U87 and U87/R cells. *P<0.05. (C) QRT-PCR and western blot analysis were performed to evaluate the expression of TAZ at the mRNA level and protein level, respectively. *P<0.05.