Research Paper Volume 11, Issue 9 pp 2670—2680

Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein

Figure 2. Role of TAZ in regulating the drug sensitivity of glioma to TRAIL. (A) Effect of TAZ siRNA on decreasing the TAZ expression in U87/R and U251/R cells. (B) Effect of TAZ plasmid on increasing the TAZ expression in U87 and U251 cells. (C) Sensitization of TAZ siRNA on TRAIL-induced cytotoxicity against U87/R and U251/R. *P<0.05 vs. TRAIL + NCO group. (D) Effect of TAZ plasmid on inducing the TRAIL resistance in U87 and U251. *P<0.05 vs. TRAIL + NCO group.