Research Paper Volume 11, Issue 9 pp 2670—2680

Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein

Figure 4. MiR-125b mimics targets TAZ to attenuate the TRAIL resistance in U251/R and U87/R. (A) MiR-125b mimics increased the drug sensitivity of U251/R and U87/R to TRAIL. (B) Effect of miR-125b mimics on reducing the IC50 of TRAIL to U251/R and U87/R. *P<0.05 vs. NCO group. (C) Transfection with TAZ plasmid inhibited the sensitization of miR-125b on TRAIL-induced cytotoxicity against U251/R and U87/R. *P<0.05 vs. TRAIL + NCO group. #P<0.05 vs. TRAIL + miR-125b group. (D) Anti-miR-125b decreased the drug sensitivity of U251 and U87 to TRAIL. *P<0.05 vs. NCO group. #P<0.05 vs. TRAIL + NCO group.