Research Paper Volume 11, Issue 9 pp 2681—2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Figure 3. Overexpression of SLC41A1 suppresses in vitro PDAC cell proliferation and induces apoptosis. (A) Overexpression of SLC41A1 reduced the growth rate of PDAC cells KP3 and Panc-1. (B) Overexpression of SLC41A1 suppressed colony formation. (C) SLC41A1 induced the formation of apoptotic-like PDAC cells. (D) SLC41A1 suppressed the invasion of PDAC cells through the extracellular matrix. *p < 0.05; **p < 0.01; ***p < 0.001.