Research Paper Volume 11, Issue 9 pp 2681—2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Figure 5. Mg2+-dependent Akt/mTOR inhibition mediates the proliferation inhibitory effects of SLC41A1 in PDAC. (A) Overexpression of SLC41A1 reduced the activation of Akt/mTOR signalling. (B) Treatment with the Akt activator SC79 partially recovered the cellular proliferation inhibited by SLC41A1. (C) Mg2+ supplementation abrogated the proliferation inhibition by SLC41A1. (D) Mg2+supplementation abrogated the inhibition of colony formation by SLC41A1.