Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Jing Xie; Chien-shan Cheng; Xiao Yan Zhu; Ye Hua Shen; Li Bin Song; Hao Chen; Zhen Chen; Lu Ming Liu; Zhi Qiang Meng

doi:doi:10.18632/aging.101940

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Research Paper Volume 11, Issue 9 pp 2681—2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Figure 6. Mg²⁺-dependent Akt/mTOR inhibition mediates the apoptosis induction and invasion suppression effects of SLC41A1 in PDAC. (A) Mg²⁺ supplementation abrogated apoptosis induction by SLC41A1. (B) Mg²⁺supplementation abrogated the inhibition of invasion by SLC41A1. (C) Overall mechanisms underlying the anti-tumour effects of SLC41A1 in PDAC.