Research Paper Volume 11, Issue 9 pp 2681—2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Figure 6. Mg2+-dependent Akt/mTOR inhibition mediates the apoptosis induction and invasion suppression effects of SLC41A1 in PDAC. (A) Mg2+ supplementation abrogated apoptosis induction by SLC41A1. (B) Mg2+supplementation abrogated the inhibition of invasion by SLC41A1. (C) Overall mechanisms underlying the anti-tumour effects of SLC41A1 in PDAC.