Research Paper Volume 11, Issue 9 pp 2735—2748

RON and RONΔ160 promote gastric cancer cell proliferation, migration, and adaption to hypoxia via interaction with β-catenin

Figure 3. Role of RON/RONΔ160 in the activation and nuclear translocation of β-catenin. (A) MGC-803 cells were transfected with RON and RONΔ160 and immunostained for RON and β-catenin. (B) Nuclear translocation ratio of β-catenin in different groups of MGC-803 cells. (C) Immunostaining for RON and β-catenin in KATOIII cells transfected with siRNA targeting RON. (D) Nuclear translocation ratio of β-catenin in different groups of KATOIII cells. (E) and (F) MGC-803 cells were transfected with RON or RONΔ160 and immunostained for RON or RONΔ160. ** p<0.01 vs Blank group. Scale bar = 50 μm in all panels.