Research Paper Volume 11, Issue 9 pp 2735—2748

RON and RONΔ160 promote gastric cancer cell proliferation, migration, and adaption to hypoxia via interaction with β-catenin

Figure 7. Effect of RON/β-catenin signaling on tumor growth of KATOIII cells. (A) Flowchart showing the experimental protocol for the xenograft model. (B) Xenografted tumors were injected with RON and/or β-catenin siRNAs twice per week. The mice were sacrificed and the tumor was collected 28 days after initial injection. (C) Statistical analysis of the tumor growth curves. (D) Xenografted tumors were injected with RON siRNAs twice a week and with anti-RON antibodies once a week. The mice were sacrificed and the tumor collected 28 days after initial injection. (E) Statistics of tumor volume and weight in the different groups. (F) Western blots showing tumoral levels of RON, c-Myc, cyclin D1 and survive proteins. ** p<0.01 vs RON NC; ## p<0.01 vs RON siRNA.