Research Paper Volume 11, Issue 10 pp 2968—2997

The small non-coding RNA profile of mouse oocytes is modified during aging

Figure 3. Predicted mRNA targets of differentially expressed endo-siRNA and miRNA. Endo-siRNA and miRNA sequences determined to be differentially expressed between young and aged oocytes (i.e. threshold of ≥ 2-fold change and false discovery rate of < 0.05) were surveyed using NCBI and miRDB target prediction algorithms, respectively to identify putative mRNA targets. The number of mRNA targets of (A) endo-siRNA and (B) miRNA predicted on the basis of this analysis are depicted.