Research Paper Volume 11, Issue 9 pp 2762—2786

MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1

Figure 9. miR-191 reduces the nucleoprotein VEZF1, resulting in up-regulation of CITED2 and down-regulation of MMP-1, STMN1 mRNA. This, in turn, suppresses HUVEC proliferation and migration and thus prevents endothelial tube formation and spheroid sprouting. Moreover, miR-191 suppresses the expression of EDN1 which functions as maintaining vascular tension.