Research Paper Volume 11, Issue 9 pp 2787—2796

The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes

Figure 2. ORMDL3 levels slightly increase in NOD mouse islets before diabetes onset, but continue decreasing after diabetes onset. (A–C) RT-qPCR for ORMDL3 (A), BIP (B) and CHOP (C) in islets from female NOD mice, at 8 weeks of age (8 weeks), the first time when fasting blood glucose reaches 150mg/dl (before diabetes onset, BDO), and 2 or 4 or 6 weeks after BDO. WT: wildtype female C57BL/6 mice at 8 weeks of age. *p<0.05. NS, no significance. N=5.