Figure 1. Phloretin decreased blood glucose concentrations, but did not affect body weight. The chemical structure of phloretin (PHL, A). Diabetes mellitus was induced in male C57BL/6 mice by a single intraperitoneal (i.p.) injection of STZ and mice with fasting-blood glucose > 12 mM were considered as diabetes and then diabetic mice were orally treated with PHL (20 mg/kg), or vehicle by gavage once every two days for 8 weeks (n =8 in each group), which was administrated in diabetic mice. In this process, the blood glucose (B-C) and body weight (D-E) were monitored once every week. **P < 0.01 v.s. T1DM group; ##P < 0.01 v.s. CTRL group.