Research Paper Volume 11, Issue 9 pp 2822—2835

Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model

Figure 1. Phloretin decreased blood glucose concentrations, but did not affect body weight. The chemical structure of phloretin (PHL, A). Diabetes mellitus was induced in male C57BL/6 mice by a single intraperitoneal (i.p.) injection of STZ and mice with fasting-blood glucose > 12 mM were considered as diabetes and then diabetic mice were orally treated with PHL (20 mg/kg), or vehicle by gavage once every two days for 8 weeks (n =8 in each group), which was administrated in diabetic mice. In this process, the blood glucose (B-C) and body weight (D-E) were monitored once every week. **P < 0.01 v.s. T1DM group; ##P < 0.01 v.s. CTRL group.