Research Paper Volume 11, Issue 10 pp 3041—3054

LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis

Figure 3. Effects of HMMR-AS1 on proliferation, apoptosis, and cell cycle of LUAD cells in vitro and in vivo. (A, B) The apoptotic rates and cell cycle of cells were determined by flow cytometry after HMMR-AS1 knockdown in NCI-H23 and A549 cells. (C, D). Tumor volume and weight were detected in tumor tissues of nude mice injected with HMMR-AS1 knockdown NCI-H23 cells. (E) Ki67 level and apoptosis were detected by TUNEL staining and immunohistochemistry, respectively. *P < 0.05, **P < 0.01.