Research Paper Volume 11, Issue 9 pp 2874—2888

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Figure 1. Median fold-change and interquartile range for circulating metabolites (post-treatment vs pre-treatment) in the standard neodjuvant regimen arm (A), the metformin plus standard regimen arm (B), and in patients on metformin compared with those not exposed to metformin (C). Metabolites with statistically significant absolute change on Wilcoxon signed rank test are shown with p-values.