Research Paper Volume 11, Issue 10 pp 3055—3079

MiR-320a induces diabetic nephropathy via inhibiting MafB

Figure 1. MiR-320a was increased in the kidney of diabetic mice. (A) Urinary ACR was determined every four weeks since the age of 8 weeks. (B) Serum creatinine and (C) BUN were detected at the age of 24 weeks. (D) Representative images of PAS staining of kidneys from C57BL/Ks and db/db mice. Scale bar, 50 μm. (E) Representative images of immunohistochemical staining of Desmin. Scale bar, 50 μm. (F) Relative miR-320a expression in renal cortex measured by real-time PCR. Data are expressed as mean ± SEM, n=8, *P<0.05 versus C57BL/Ks.