Research Paper Volume 11, Issue 10 pp 3117—3137

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Figure 1. Zebrafish retinal mtDNA quality at different ages and after resveratrol treatment. (A, C) The bands in the left lane are DNA size markers. The top slice shows the long mitochondrial fragments (mit-L) while the bottom slice shows the short mitochondrial fragments (mit-S). The graphs show the ratio of mit-L/mit-S by densitometry analysis of each band (mean ± SEM, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, n=3) (B) Comparison of mitochondrial copy number (mitCN) in 5 days, 1 month, 4 months, and 19 months old zebrafish retinas (mean ± SEM, ***P<0.001, ****P<0.0001 , n=3.) (D) Comparison of mitCN in zebrafish retinas after treatment with 20mg/L resveratrol for 1 or 10 days (mean ± SEM, **P<0.01 compared to control, n=3.). CON, control. RES1d, resveratrol treated for 10 days; RES10d, resveratrol treated for 10 days.