Research Paper Volume 11, Issue 10 pp 3117—3137

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Figure 11. Schematic representation of resveratrol induced activation of AMPK/ SIRT1/ PGC1α and inhibition of mTOR, leading to increased mitochondrial quality. Resveratrol treatment enhances AMPK/SIRT1/PGC1α expression and decreases mTOR signaling, which leads to an increase in mtDNA quality and enhanced energy metabolism at least partly through decreased mitochondrial fragmentation and increased autophagy/mitophagy.