Research Paper Volume 11, Issue 10 pp 3117—3137

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Figure 3. Resveratrol treatment increased mitochondrial fusion/fission expression in young zebrafish retina. (A-D) Mfn2, Opa1, Oma1, and Fis1 gene expression after resveratrol treatment for 1 or 10 days as determined by quantitative real-time PCR (mean ± SEM, *P<0.05, **P<0.01, ***P<0.001 compared to control (CON), n=3). (E) Immunofluorescence localization and relative expression of Mfn2 in the RGC layer of adult zebrafish retina cross-sections after 10 days resveratrol treatment. All photographs were taken at 40x magnification. CON, control; RES1d, resveratrol treated for 1 days; RES/RES10d, resveratrol treated for 10 days; GCL, ganglion cell layer.