Research Paper Volume 11, Issue 10 pp 3262—3279

Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

Figure 4. Differences in the relative abundance of various gut microbes among CONT, CD, and Non-CD mice. (AP) Relative abundances of (A) phylum Actinobacteria (one-way ANOVA; F2,25 = 7.958, p < 0.01), (B) class Gammaproteobacteria (one-way ANOVA; F2,25 = 4.597, p < 0.05), (C) class Mollicutes (one-way ANOVA; F2,25 = 4.035, p < 0.05), (D) order Enterobacteriales (one-way ANOVA; F2,25 = 3.385, p = 0.05), (E) order Lactobacillales (one-way ANOVA; F2,25 = 3.277, p > 0.05), (F) family Aerococcaceae (one-way ANOVA; F2,25 = 6.019, p < 0.01), (G) family Odoribacteraceae (one-way ANOVA; F2,25 = 20.67, p < 0.001), (H) family Porphyromonadaceae (one-way ANOVA; F2,25 = 5.597, p < 0.01), (I) family Prevotellaceae (one-way ANOVA; F2,25 = 4.528, p < 0.05), (J) family Rikenellaceae (one-way ANOVA; F2,25 = 4.938, p < 0.05), (K) genus Aerococcus (one-way ANOVA; F2,25 = 7.863, p < 0.01), (L) genus Helicobacter (one-way ANOVA; F2,25 = 4.135, p < 0.05), (M) genus Odoribacter (one-way ANOVA; F2,25 = 20.78, p < 0.001), (N) genus Parabacteroides (one-way ANOVA; F2,25 = 5.597, p < 0.01), (O) genus Unclassified (one-way ANOVA; F2,25 = 5.114, p < 0.05), and (P) species Parabacteroides distasonis (one-way ANOVA; F2,25 = 7.235, p < 0.01). Data are shown as mean ± SEM (n = 8−10 individual fecal samples/group). *P < 0.05, **P < 0.01 or ***P < 0.001. ANOVA: analysis of variance; CD: cognitive dysfunction; CONT: control; N.S.: not significant; SEM: standard error of the mean.