Research Paper Volume 11, Issue 10 pp 3262—3279

Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

Figure 8. Changes in the gut microbiota of pseudo-germ-free mice following transplantation from CD and Non-CD diabetic mice. (A) Unweighted unifrac diversity distance. (B) Shannon index (one-way ANOVA; F3,24 = 0.928, p > 0.05). (C) Simpson index (one-way ANOVA; F3,24 = 0.486, p > 0.05). (D) PCoA analysis of gut bacteria data (PC1 versus PC2). (E) PLS-DA analysis of gut bacteria data. The α-diversity is shown as mean ± SEM (n = 7 individual samples/group). ANOVA: analysis of variance; CD: cognitive dysfunction; CONT: control; N.S.: not significant; PCoA: principal coordinate analysis; PLS-DA: partial least squares discrimination analysis; SEM: standard error of the mean.