Research Paper Volume 11, Issue 10 pp 3280—3297

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease

Figure 5. Transcript levels of selected inflammation- and apoptosis-related genes and BDNF protein expression in the striatum at 7 days after MPTP administration. (AE) Inflammation-related gene transcripts. (A) TNFα. (B) iNOS; (C) IL-1α. (D) IL-1β. (E) IL-6. N = 3–11. (FI) Apoptosis-related gene transcripts. (F) Bax. (G) Bid. (H) Mapk11. (I) Fas. N = 7–9. (J) Western blot analysis of BNDF expression in the striatum. Quantification of relative BDNF expression levels is shown in the right panel. N = 3. Data are means ± SEM. Data were analyzed by one-way ANOVA. **p < 0.01, ***p < 0.001, vs saline-treated control; #p < 0.05, ##p < 0.01, vs MPTP-treated WT mice.