Research Paper Volume 11, Issue 10 pp 3280—3297

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease

class="figure-viewer-img"

Figure 7. Late assessment of neurogenesis. (A) Immunohistochemical staining of BrdU in the SVZ, 42 days after MPTP/saline treatment. Scale bar: 200 μm. Quantification of BrdU-positive cells is shown in the right panel. Data are means ± SEM. Data were analyzed by one-way ANOVA. *p < 0.05, **p < 0.01, vs saline-treated control; #p < 0.05, vs MPTP-treated WT mice. N = 4. (B) Immunofluorescence staining of BrdU (red) and GFAP (green) in the SVZ. Scale bar: 100 μm.