Priority Research Paper Volume 11, Issue 10 pp 2916—2948

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

Figure 2. Immunohistochemistry of Ki67 and γH2AX in the brain. (A-F) The quantification and representative images of the immunohistochemistry for positive cells per field of view for (A-C) Ki67, and (D-F) γH2AX in brain regions such as the hippocampus, dentate gyrus, subventricular zone (SVZ) of the lateral ventricle anterior to the hippocampus level, and the neocortex. The data is shown for young and old wild-type and G3 Tert-/- mice. Data represent the mean ±SE of analyzed mice within each group. For the histopathology results, the number of mice analyzed per group is indicated, as well as the number of fields of view, and the number of positive cells. The t-test was used for statistical analysis. *p<0.05; **p<0.01; ***p<0.001.