Priority Research Paper Volume 11, Issue 10 pp 2916—2948

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

Figure 5. Treatment with AAV9-Tert results in less DNA damage in the brain. (A-B) Quantification and representative images of the histopathology for γH2AX in the (A) hippocampus, (A) dentate gyrus, and (B) neocortex for the cohort of mice (wild-type, G3 Tert-/-, and G4 Tert-/- mice) injected with 2E12 vg of AAV9-Tert or AAV9-null. (C) The level of Trp53 mRNA in the brain as measured by qPCR relative to GAPDH at the humane endpoint. Data represent the mean ±SE of analyzed mice within each group. The number of mice analyzed per group is indicated. The t-test was used for statistical analysis. *p<0.05; **p<0.01; ***p<0.001.