Priority Research Paper Volume 11, Issue 10 pp 2916—2948

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

Figure 7. Treatment with AAV9-Tert improves memory in the Barnes maze test. (A-E) Quantification of the performance in the Barnes maze test after 30 weeks of treatment for (A) number of holes searched before reaching the goal box, (B) time required to reach the goal box, (C) path length used to reach the goal box, (D) the percent of holes searched in the target quadrant, and (E) the percent time spent searching in the target quadrant. (F) Representative paths of the mice on the Barnes maze table after 30 weeks of treatment. Data represent the mean ±SE of analyzed mice within each group. The number of mice analyzed per group is indicated.