Research Paper Volume 11, Issue 10 pp 3298—3314

GDF10 inhibits proliferation and epithelial-mesenchymal transition in triple‐negative breast cancer via upregulation of Smad7

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Figure 7. Schematic model of the antitumor actions of GDF10 on TNBC cells. GDF10 expression increases Smad7 levels and inhibits the formation of Smad2/4 complexes. Overexpression of GDF10 suppresses proliferation, EMT, and invasion in TNBC cells via inhibiting the formation of Smad2/4 involving the upregulation of Smad7.