Research Paper Volume 11, Issue 10 pp 3362—3375

Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge

Figure 2. Circ-0001649 and SHPRH regulated proliferative ability of HCC cells. (A), (C), (E) CCK-8 assay, colony formation assay and EdU assay showed that upregulation of circ-0001649 inhibited the proliferation of HCC cells, which was reversed by sh-SHPRH. (B), (D), (F) CCK-8 assay, colony formation assay and EdU assay showed that downregulation of circ-0001649 promoted the proliferation of HCC cells, which was reversed by SHPRH. *P < 0.05 versus control group, #P < 0.05 versus circ-0001649 or sh-circ-0001649 group, data represent the mean ± SD.