Figure 4. Circ-0001649 regulated in vivo proliferation of SMMC-7721 cells. (A) Representative images of xenografts tumor (four mice per group) in nude mice. (B) Tumor growth curves were measured after injection of SMMC-7721 cells transfected with sh-circ-0001649 or sh-NC. (C) Tumor weights were measured. (D) Ki-67, SHPRH and E-cadherin IHC staining. *P<0.05, data represent the mean ± SD.