Research Paper Volume 11, Issue 10 pp 3362—3375

Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge

Figure 7. Graphical abstract of how circ-0001649 inhibits hepatocellular carcinoma progression. A schematic model of circ-0001649/miRNAs/SHPRH signaling pathway in hepatocellular carcinoma. circ-0001649 competitively binds to miR-127-5p, miR-612 and miR-4688, resulting in upregulation of SHPRH. Furthermore, upregulation of SHPRH inhibits the clonogenicity, migration and proliferation of HCC cell lines.