Research Paper Volume 11, Issue 11 pp 3561—3573

Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis

Figure 6. Schematic representation of the proposed mechanism of circ_0132266 in CLL. circ_0132266 acts as a miR-337-3p sponge to regulate the miR-337-3p/PML pathway. Decreased circ_0132266 in CLL leads to the upregulation of miR-337-3p, which eliminates the suppression effects of PML in CLL progression.