Research Paper Volume 11, Issue 11 pp 3585—3600

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

Figure 3. Knockdown of H19 reduced neuronal injury and neuronal apoptosis in vivo. (A) After a single intracerebroventricular injection of H19 siRNA in MCAO/R rats, significant reductions in neurological deficit were observed in H19 siRNA group at 3 d and 7 d post MCAO/R, when compared to the NS group or mis siRNA group. (B) Significant reductions in infarct volumes were also seen in rats of H19 siRNA group, compared with NC group or mis siRNA group. (C) There was a significant decrease in the number of TUNEL-positive cells in the H19 siRNA group compared to NC group or mis siRNA group.