Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 10. Schematic representation of the putative anti-atherogenic action of AAV1-shAngptl2. Elimination of angptl2+:p21+ senescent endothelial cells by apoptosis promotes endothelial repair. This leads to a reduced inflammatory profile, a lower immune cell adhesiveness and infiltration and therefore, a reduced atherogenicity.